Effects of 6-hydroxydopamine on 14C-dopamine uptake in isolated rabbit renal artery
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چکیده
منابع مشابه
Local Sympathetic Denervation of Femoral Artery in a Rabbit Model by Using 6-Hydroxydopamine In Situ
Both artery bundle and sympathetic nerve were involved with the metabolism of bone tissues. Whether the enhancing effects of artery bundle result from its accompanying sympathetic nerve or blood supply is still unknown. There is no ideal sympathetic nerve-inhibited method for the in situ denervation of artery bundle. Therefore, we dipped the femoral artery in the 6-hydroxydopamine (6-OHDA) loca...
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Conserved dopamine neurotrophic factor (CDNF), a member of the mammalian mesencephalic astrocyte-derived neurotrophic factor family of conserved secreted factors, has been reported to protect and rescue dopaminergic neurons in vivo. PC12 pheochromocytoma cells are widely used as a cell model for Parkinson's disease (PD) for experimental studies. In the present study, PC12 cells were induced usi...
متن کاملThe uptake of dopamine-14C and its conversion to noradrenaline-14C in rats.
The scheme of biosynthesis of noradrenaline from dopa in the mammalian tissues was presented by Blaschko (1). The conversion of dopamine to noradrenaline, mediated by dopamine-Q-hydroxylase (2), was shown to occur in the intracellular granules of the adrenal medulla (3) and heart (4, 5). The administration of tyrosine-14C (6) or dopa 14C (7 , 8) to rats results in formation of noradrenaline-14C...
متن کاملA comparison of the effects of 5- and 6-hydroxydopamine on the isolated canine saphenous vein.
We studied and compared the effects of 5- and 6-hydroxydopamine (5- or 6-OHDA) on venous tone and on adrenergic and nonadrenergic responses of the isolated canine saphenous vein. In the tissue bath, both 5- and 6-OHDA caused increases in tone and abolished adrenergic responses to transmural nerve stimulation. Effects of 6-OHDA were blocked by desmethylimipramine. 6-OHDA reduced norepinephrine l...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1976
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)65917-2